The Swiss top seed needed only 16 minutes to wrap up the first set and next faces Kevin Anderson who battled past Frenchman Gael Monfils 7-6(4) 7-6(2) 5-7 7-6(4).
Rafael Nadal was equally brutal in his 6-3 6-3 6-4 win over Jiri Vesely to book a quarter-final spot for the first time since 2011.
Former champion Novak Djokovic dismissed Russia’s Karen Khachanov 6-4 6-2 6-2 to reach the last eight.
Djokovic, three-times winner at the All England Club, next meets 24th seed Kei Nishikori of Japan who beat Latvia’s Ernests Gulbis 4-6 7-6(5) 7-6(10) 6-1.
Seven-times champion Serena Williams powered past Russian qualifier Evgeniya Rodina, posting her 90th singles match win at the All England Club with a 6-2 6-2 victory.
German 11th seed Angelique Kerber ensured she was the highest-seeded player remaining in the women’s draw with a 6-3 7-6(5) win over Switzerland’s Belinda Bencic.
Japan’s Kei Nishikori converted two out of eight break point opportunities and hit 47 winners as he overcame Latvia’s Ernests Gulbis 4-6 7-6(5) 7-6(10) 6-1 on Court Two.
American John Isner advanced with a 6-4 7-6(8) 7-6(4) win over Greek Stefanos Tsitsipas. joining him in the last eight was Canadian Milos Raonic who downed American Mackenzie McDonald 6-3 6-4 6-7(5) 6-2.
Julia Goerges, whose previous five Wimbledon campaigns ended in the first round, produced a clinical display to beat Donna Vekic 6-3 6-2 in their fourth-round clash. The German 13th seed prevailed in 75 minutes and meets Kiki Bertens next.
Seventh-seeded Czech Karolina Pliskova suffered a 6-3 7-6(1) defeat by Kiki Bertens on Monday. With Pliskova’s exit, the top 10 seeds in the women’s draw have crashed out of the tournament.
Dominika Cibulkova powered past Taiwan’s Hsieh Su-wei 6-4 6-1 while Jelena Ostapenko came from 5-2 down in the first set to knock out Aliaksandra Sasnovich 7-6(4) 6-0.